Bioluminescence Imaging Detection Service
Bioluminescence imaging detection is currently widely used in vivo detection technology. Its principle is to use the combination of luciferin and luciferase to consume ATP and oxygen to produce photons to convert chemical energy into detectable photon signals. The bioluminescence technology used in the living body inserts the luciferin gene into the cell chromosome and expresses it so that the number of luminescence per cell and the luminescence conditions are stable.
Since the animal itself does not have any self-luminescence, bioluminescence has an extremely low background and extremely high signal noise Compared with it, which can reach the precision of detecting 102 cells and has extremely high sensitivity. Even if the labeled cells have complex positioning in the animal body, the relative number of luminescent cells can be measured from the signal level of the animal's body surface, and the detection effect is better for deep tissues. Bioluminescence detection is flexibly used in biological detection, tracing in living animals, intracellular subcellular structure detection, and component positioning.
Fig1. The theory and work flow of bioluminescence imaging detection
We focus on high precision, high specificity, high integration, and provide bioluminescence imaging detection experimental services. The purpose of our service is to provide accurate and reliable bioluminescence imaging detection services through complete experimental design and highly integrated experimental design matching experimental needs, helping all animal models in vivo tumor research, infection research and cell research researchers Complete the test work, your success is our success.
We provide but are not limited to:
- A customize detection plan to meet your requirement specificity.
- Single or multiple marker design for your detection, aiming at one point or a group to verify.
- We provide image process surveys to help you go further into data.
Advantages of bioluminescence imaging detection service:
- High sensitivity: many substances in the organism will also excite fluorescence under the excitation light. Fluorescence imaging can detect 104 cells, and bioluminescence can only detect 102 cells.
- Facilitate deep tissues analysis: such as 3-4 cm, the effect of bioluminescence is better.
- Bioluminescence imaging detection service can promise the data will be stable even if the targets have a complicated location.
We can do furthermore:
- We can provide a consultative service to make sure your bioluminescence imaging detection gong well.
- We can offer other services attached to bioluminescence imaging detection service like gene recombination and antibody prepare service to make your work simpler.
- Our bioluminescence imaging detection service include data analyze and visualized to save your time.
References
- Su Y. Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals. Nature Methods, 2020, 17(8):1-9.
- Vary C P. Nonisotopic detection methods for strand displacement assays of nucleic acids. Clinical Chemistry,2020, (9):9.
- Lim W. Bioluminescence and near-infrared fluorescence imaging for detection of metastatic bone tumors. Lasers in Medical Science, 2019(2).
*For Research Use Only. Not for use in diagnostic procedures.