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The Discovery and Optimization of Nucleic Acid Drug Candidates

Creative Biolabs helps clients turn hits from screening into lead compounds that can be further optimized, realizing the discovery of nucleic acid drug candidates. The lead compound can be a screened hit or a series of homologues. For high-throughput screening, there are discrete and multi-series hits. This requires the selection of one of the series for further study, which is the process of Hit to Lead. Creative Biolabs has advanced computing tools, highly automated analytical instruments and efficient integration capabilities to help customers achieve this. The selection of a lead compound for preclinical evaluation can transform it into a nucleic acid drug candidate and optimize the lead compound. Creative Biolabs is capable of conducting pharmacokinetic and pharmacodynamic studies. When modifying lead compounds, we can assist customer to observe the changes of physical and chemical properties. For compounds with no selectivity, we can use off - target effect and other technical means to further study.

Services We Can Provide:

1. Chemical Modifications of Nucleic Acid Drug

Creative Biolabs can supply professional customized service about the chemical modifications of nucleic acid drugs and support of your research and technology appliance.

We provide but are not limited to:

  • Chemical modified nucleotide
  • Oligonucleotide conjugatives

Categories of Chemical Modifications:

  • Chemical modification of nucleotides
  • Covalent conjugation of nucleic acids

The usage of synthetic oligonucleotides for clinical applications has proven to be a rapid and rational method for drug discovery. Creative Biolabs can get oligonucleotide-based compounds with drug-like properties by placing the chemical modifications in their structure. To achieve these, the chemical structure of the oligonucleotide needs to be optimized through various modifications including sugar, backbone, nucleobase, and 3'- and 5'-terminal and conjugate modifications.

2. Targeting Delivery Analysis Service 

Using vector technology and targeting delivery system, Creative Biolabs can help clients improve the biological activity of nucleic acid drugs, improve distribution in vivo, enhance targeting and uptake ability to cells and improve the concentration and bioavailability of drugs in target tissues.

Classification of targeting delivery system of nucleic acid drugs:

  • Liposome.
  • Cationic polymer compound.
  • Polypeptide protein delivery vector.
  • Dendrimers (DEN) and various polymers.
  • Active targeting nanoparticles.
  • Targeting delivery system mediated by ligand based on specific receptor.

We provide but are not limited to:

  • Peptide modification.
  • Aptamer-cationic polymer-siRNA system.

3. Evaluation of Specific Receptor Affinity

Creative Biolabs can provide you with many evaluation methods:

  • Radio-ligand receptor binding assay.
  • Affinity chromatography.
  • Liquid scintillating counting.

4. Oligonucleotide Drugs Structure-Activity Relationship Analysis

Creative Biolabs has rich practical experience and core technology in the research of quantitative structure-activity relationship, providing efficient and high-quality technical services for the majority of scientific researchers and companies.

Creative Biolabs can provide you with many services of structure-activity relationship:

  • 2D-QSAR.
  • 3D-QSAR.

5. In Vitro and In Vivo Stability Analysis of Oligonucleotide Drugs

The stability study is an important factor related to whether the drug can be put into the market, and is also an essential condition for the promotion and application of drugs with good efficacy and low toxicity.

Creative Biolabs can provide you with many services of in vitro and in vivo stability:

  • Influence factor experiment.
  • Accelerated test.
  • Long-term test.

6. In Vivo Activity Evaluation of Oligonucleotide Drugs

Creative Biolabs has an experienced technical team that can provide in vivo activity evaluation and screening services for a variety of drugs. Creative Biolabs can assist customers in the evaluation of biological activity, pharmacological effects and clinical applications to save research and development costs and shorten research time.

Creative Biolabs can provide you with many services of in vivo activity evaluation:

  • Hollow fiber assay.
  • Transplanted tumor model.
  • Efficacy test of anti-cerebral ischemia drugs.

7. Exposure-Effects Analysis Service

Study on the relationship between drug exposure and effects is a key part of the drug discovery process.

Creative Biolabs can provide you with many services of exposure-effects analysis:

  • Parallel dose-effect study.
  • Multiple comparison.
  • Model approach.

8. In Vitro ADME Service

  • Absorption.
  • Distribution.
  • Metabolism.
  • Excretion.

Thank you for choosing our service of the discovery and optimization of nucleic acid drug candidates. If you have any questions, please contact our staff, we will answer and serve you immediately.

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*For Research Use Only. Not for use in diagnostic procedures.

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