Nucleic Acid-Oligo Bioconjugation Services - Creative Biolabs

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Nucleic Acid-Oligo Bioconjugation Services

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Nucleic Acid-Oligo Bioconjugation Services

Although oligonucleotides have been considered as a new drug for more than three decades, their therapeutic application has not fully met expectations to date. All nucleic acid drugs have poor pharmacokinetics, lack cell membrane permeability, and are often unstable and even sometimes produce off-target effects.  To realize the full potential of oligonucleotide therapy, the use of conjugated oligonucleotides is an effective approach. These conjugates are lipophilic or targeting in nature. Their main functions are to enhance targeting, promote vectorization, reduce the sensitivity of oligonucleotides to nuclease activity, eliminate or reduce the need for toxic transfection agents, and generally improve pharmacological activity and efficacy[1].

Bioconjugated oligonucleotides, including novel conjugates with peptides, proteins, carbohydrates, aptamers, small molecules and GalNAc, provide enhanced tissue targeting, cell internalization, endosomal escape, target binding specificity, resistance to nucleases, etc[2].

Nucleic Acid-Oligo Bioconjugation ServicesNovel bioconjugated oligonucleotides[1]

Our Oligo Bioconjugation Services

With our advanced synthesizers and over a decade of experience in nucleic acid drug development, we can provide custom oligonucleotide conjugation services. We have the most efficient and robust oligonucleotide conjugation technology, allowing single and double-stranded oligonucleotides to be conjugated to the molecule of your choice. Our most friendly and efficient oligonucleotide labeling kits enable the perfect combination of oligonucleotides with antibodies, enzymes, streptavidin, avidin, fluorescent proteins, biotin, etc. In addition, we can also provide reliable custom oligonucleotide conjugation services to meet your application needs for assays, antibody production, therapeutic research and more.

Quality Assurance

During synthesis, each oligonucleotide conjugate is rigorously monitored according to strict biosynthetic quality assurance and quality control standards. The final product is identified by mass spectrometry, and its high purity is ensured by high-throughput gel electrophoresis, high-performance liquid chromatography or other appropriate QC methods.

The types of bioconjugation include, but are not limited to:

Advantages:

  • Oligos-Nucleic Acid Bioconjugation
  • Quality oligo synthesis
  • Flexible bioconjugation chemistries
  • A wide choice of target molecules
  • Differenet modifications available
  • High yield
  • High purity
  • Various QC methods
  • Micrograms to grams-scale

Delivery Specifications:

  • Lyophilized sample
  • COA
  • MS/HPLC report

Since its establishment, Creative Biolabs has developed quality products with advanced technologies, and has made considerable progress in the development of oligonucleotide drugs, large-scale production of oligonucleotides, raw material drug quality research, GMP production line construction and GMP management. You can contact us for any oligonucleotide drug research and development needs.

References

  1. Sebastien Benizri.Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications. Bioconjug Chem. 2019 Feb 20; 30(2): 366-383.
  2. Winkler J. Oligonucleotide conjugates for therapeutic applications. Ther Deliv. 2013;4(7):791-809.

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*For Research Use Only. Not for use in diagnostic procedures.

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