Structure Determination Service
Accurate information of drug structure is a prerequisite for rational drug design and structure-based function research. Structure Determination is very important in drug research and development. The structure determination platform of Creative Biolabs is equipped with world advanced instruments and equipments. Scientists who perform structure determination have rich project service experience and can provide one-to-one efficient and high-quality services to accelerate the process of research on drug structure according to customer's requirement.
Structure Determination Services We Can Provide:
1. X-ray Crystallography Service
X-ray crystallography uses the scattering effect of electrons on X-rays to link X-rays with crystallography, providing reliable answers to many redundant structure-related questions such as overall folding, ligand or substrate binding and other specific information. X-ray crystallographic diffraction analysis is the most important method for determining the three-dimensional structure and function of macromolecular proteins and nucleic acids.
We provide but are not limited to:
- Determination of the molecular structure of trace or unknown compounds.
- Determination of the molecular structure of the mixture in eutectic form.
- Determination of absolute configuration.
- Conformational analysis.
- Biomacromolecule structure analysis.
2. Nuclear Magnetic Resonance Spectroscopy Service
NMR spectroscopy is suitable for all stages of pre-clinical research and development of new nucleic acid drugs, and can detect the nature of organic compounds and the interaction of their surrounding chemical environment.
We provide but are not limited to:
- Determine the spatial structure of drug target molecules.
- Analyze the structure of small molecule lead compounds and natural products.
- High-throughput screening of small molecules.
- Identify the structure-activity relationship of a drug.
- Toxicology and safety evaluation of new drugs.
3. Cryogenic Electron Microscope Service
Cryogenic electron microscopy is an important high-resolution structural biology research method, can observe samples with transmission electron microscopy at low temperatures.
We provide but are not limited to:
- Determine the structure of virus-receptor complex.
- Determine the fine structure of ribosomes, membrane proteins and other key cellular proteins.
- Determine the high-resolution structure of biomolecules in solution.
- Identify the three-dimensional structure of biological macromolecule complexes.
- Analyze the function of biological macromolecules nucleic acid drugs.
- Provide initial molecular replacement model and initial phase for X-ray crystallographic structure analysis.
4. Small Angle X-Ray Scattering Service
Small angle X-ray scattering is an important research method of biological structure. When X-rays are irradiated on the sample, if there are Nano-scale electron density uneven areas inside the sample, they will appear in a small angle range around the incident beam (generally 2θ≤5%) scatter X-rays. Small-angle X-ray scattering is particularly sensitive to the inhomogeneity of electron density. Any material with Nano-scale electron density inhomogeneity will cause small-angle scattering.
We provide but are not limited to:
- Qualitative analysis of the structure of biological macromolecules.
- Identify morphological changes of biological macromolecules.
- Quantitative study of the long program size of biological macromolecule samples.
- Analysis of the long-range law of protein and its complex sample parameters.
- Determination of molecular parameters of biological macromolecules.
- Analyze the conformation of biological macromolecules.
5. Neutron Scattering Service
Neutron scattering means that after a beam of neutrons is scattered by a sample, the structure and microscopic motion laws of various biological macromolecular substances on the atomic and molecular scale are studied by measuring the changes in their energy and momentum.
Creative Biolabs can provide you with many services of neutron scattering:
- Determine the size of biological macromolecules.
- Study the structure of biofilms.
- Identify the shape of ribosomes.
- Distinguish the isotopes of biological macromolecules.
- Locate the position and state of hydrogen atoms and water molecules in biological macromolecules.
- Study the structure of biological macromolecule complexes.
- Study the dynamics of biological macromolecules.
Inquiry and order
Creative Biolabs is a professional biotechnology service platform that provides pre-clinical evaluation technology. Thank you for choosing our service of structure determination. If you have any questions, please contact our staff, we will answer and serve you immediately.
*For Research Use Only. Not for use in diagnostic procedures.