Custom RNA Oligo Synthesis Services

As an important research tool, RNA oligonucleotides (oligos) are widely used in gene function analysis and the development of new therapeutics and other research applications. Creative Biolabs provides high-quality and diverse RNA chemically synthesis services, including customizable single/dual stranded RNA oligonucleotides, modified RNA oligos, stable siRNA, miRNA, long RNA and other antisense RNA synthesis, to meet the different needs of our customers. All of our RNA products will be tested by mass spectrometry and HPLC to ensure high quality.

The Methods of RNA Synthesis

In the 1980s, a basic strategy for synthesizing DNA oligomers, the phosphoramidite approach, was established by Caruthers and Beaucage. This approach was proven to be so reliable that it can be well applied to the automatic synthesis of DNA fragments using synthesizers. The present requirement in molecular biology also expands toward the stage of synthesizing oligodeoxynucleotides with the length of more than 100 bases. In the current synthesis of RNA, several methods have been utilized by custom synthesis companies that supply oligoribonucleotides with moderate nucleotide length of up to 50 mer as sufficiently pure products. At present, long RNA oligomers which have more than 100 nt can be synthesized. With an increase of the RNA length demanded by researchers in molecular biology, organic chemists should search for more effective methods for the synthesis of 200 mer-level RNA oligomers. For this purpose, the choice of a more suitable 2'-hydroxyl protecting group is inevitable and essential^[1].

Synthesis cycle of DNA and RNA^[1]

Our RNA Synthesis Services include but are not limited to the ones listed below:

• miRNA Synthesis Services
• Locked Nucleic Acid Synthesis Services
• Aptamer Screening Services
• CRISPR crRNA, tracrRNA, gRNA Synthesis Services 
• shRNA Synthesis Services
• Long RNA Synthesis
• siRNA and UsiRNA Synthesis
• RNAi Synthesis
• RNA Sequencing Primer Synthesis
• Chimeric Oligo Synthesis

Specification of our Services:

Competitive Advantages:

• Flexible synthesis scales
• Bulk orders are available upon request.
• Stringent quality control
• High-quality and cost-effective
• Both unmodified and modified RNA oligos are available.
• Comprehensive backbones
• Fast turnaround: 5-10 business days

Delivery:

• Synthetic RNA lyophilized powder
• COA
• Test report (MS & HPLC)

We offer a wide range of RNA modifications. We can also provide some special modifications (please contact us to inquire). Below is a list of the most frequently requested modifications.

Reference

1. Satoshi Obika, Mitsuo Sekine. Recent Development of Chemical Synthesis of RNA. Synthesis of Therapeutic Oligonucleotides. 41-42 (2018)

*For Research Use Only. Not for use in diagnostic procedures.

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