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In Vitro Toxicological Evaluation

Creative Biolabs provides a variety of efficient in vitro toxicology evaluation services to support early drug development and lead compound selection/optimization. According to customer requirements, Creative Biolabs carries out advanced in vitro toxicity screening methods to evaluate the toxicity tendency and structure-toxicity relationship of new compounds, helping customers select and optimize new drugs at the early stage of development. Creative Biolabs is able to report the results of various analytical methods and dose-dependent relationships quickly and timely, so that customers can know the potential toxicity of the tested substances and optimize the compounds with a high probability of success as soon as possible.

In VitroToxicological Evaluation Services We Can Provide:

1. High-Throughput Screening (HTS) And High-Content Screening (HCS) Platform

HTS and HCS platform is a widely used technique in the early stage of drug development, which can be applied to multiple aspects of compound detection. Its main advantage is that it can screen a large number of samples at the same time and provide the information with reference value quickly. HTS and HCS toxicity screening can detect the toxicity of a large number of compounds simultaneously, helping customers reduce the development time significantly.

Creative Biolabs can use the HTS and HCS platform to provide you with a variety of in vitrotoxicity evaluation services:

  • Live/dead cell testing.
  • Cell viability assay.
  • Mitochondrial health.
  • DNA damage and repair.
  • Apoptosis - Caspase analysis / Tunel analysis.

2. Hepatotoxicity Analysis Service

Drug metabolism and detoxification mainly occur in the liver, so the liver is the most easily affected organ by drugs. Hepatotoxicity is one of the items that must be tested for drug safety. Early detection of potential toxicity can lead to significant savings in development cost and improve drug conversion rates.

Creative Biolabs can provide you with many models of hepatotoxicitya evaluation services:

  • In vivo. 1. Assay for serum enzyme of hepatocyte injury; 2. Liver function tests.
  • In vitro. 1. Liver Perfusion; 2. Primary culture of liver cells.
  • Cytochrome P450 enzyme system (CYP450).

3. Cardiotoxicity Analysis Service

The cardiac toxicity of drugs mainly manifests in the inhibition of cardiac cell ion channels, which affects the normal electrophysiological activities of cardiac cells, usually leading to prolonged QT interval and arrhythmia. And sudden cardiac death can occur in severe cases. Cardiotoxicity is a major obstacle to drug development.

Creative Biolabs can provide you with many models of cardiotoxicity evaluation services:

  • hERG assay.
  • In vitro heart perfusion study model.
  • Bio-telemetry.

4. Neurotoxicity Analysis Service

The nervous system plays an important role in the physiological regulation of the whole body. Nervous system dysfunction can do harm far beyond the nervous system itself, and other system dysfunction can also change the function of the nervous system. Damage to the nervous system is one of the manifestations of drug poisoning. Neurotoxicity is a relatively hidden toxic reaction. Once neurotoxic drugs enter the clinical stage, their harm is hard to be noticed and found. However, the nerve damage caused by them is often serious and irreversible, so the screening of neurotoxicity is of great significance.

Creative Biolabs can provide you with many models of neurotoxicity evaluation services:

  • Induced pluripotent stem cells (iPS cells).
  • 2D neuronal drug screening and toxicity testing.
  • Drug screening and toxicity testing of 3D cerebral organoids.
  • Related cell function evaluation techniques and methods.

5. Nephrotoxicity Analysis Service

The kidney is the important organ of the human body, and is the main way to get drugs and their metabolites out of the body. The kidney is particularly vulnerable to drugs, which can have a direct toxic effect on the kidney or cause kidney damage through an allergic reaction. Nephrotoxicity can be detected early in the corresponding cell or animal model, providing important reference for drug development.

Creative Biolabs can provide you with many models of neurotoxicity evaluation services:

  • NGAL.
  • Nephrotoxicity PCR Array.
  • Zebra fish.

6. Genotoxicity Analysis Service

Genotoxicity refers to those that cause heritable changes in the chromosomes of germ cells. In early toxicity tests, the detection of a drug's genotoxicity is usually consistent with the detection of its carcinogenic toxicity. Genotoxicity may have more serious consequences than other organ toxicity, because it is related to gene mutation and chromosomal aberrations and can be amplified or inherited. Genotoxicity includes changes in DNA structure and DNA damage that does not involve structural changes. The detection items of genotoxicity test mainly include gene mutation, chromosome structure and number abnormalities, single/double strand breaks of DNA and so on.

7. Endocrine Disruption Analysis Service

When drugs interfere with the endocrine system, they may cause developmental abnormalities, reproductive disorders, increased risk of cancer abnormal immune function and impaired nervous system function. Sex hormone levels are most often affected.

Creative Biolabs can provide you with many models of endocrine disruption evaluation services:

  • The estrogen receptor binding assay.
  • The androgen receptor binding assay.
  • The estrogen receptor transcriptional activation (ERTA) assay.

8. Mitochondrial Toxicity Analysis Service

Mitochondria are the main site of energy metabolism in cells to generate ATP, and they play a very important role in the regulation of cell growth, proliferation, differentiation and death. Mitochondrial damage is an important feature of the toxic effects of many drugs. Mitochondrial toxicity has become an important factor in the failure of drug development or the limitation of clinical application. In addition, some drugs are required to be marketed for reevaluation because of the risk of mitochondrial toxicity. Mitochondrial toxicity is an important part of the safety evaluation of drug candidates.

Creative Biolabs can provide you with many models of mitochondrial toxicity evaluation services:

  • Mitochondrial membrane potential assay.
  • Reactive oxygen species assay.
  • ATP content detection.

9. Drug-Drug Interaction Analysis Service

Drug-drug interaction (DDI) refers to the phenomenon that concurrent drugs affect each other's drug activity by inducing or inhibiting drug metabolic enzymes or transporters during the process of absorption, distribution, metabolism and excretion (ADME). This process may cause abnormal changes in drug metabolism, resulting in abnormal increases or decreases in blood drug concentration, that may lead to severe side effects or diminished efficacy. DDI is a test item recommended by the FDA for new drug development.

Creative Biolabs can provide you with many models of DDI evaluation services:

  • Cytochrome P450 (CYP450) enzyme induction/inhibition assay.
  • UDP-glucuronosyltransferase (UGT) inhibition assay.
  • Drug transporter assay.

Advantages of In Vitro Toxicological Evaluation Services:

  • International leading technology platform and top scientists team.
  • Familiar with the regulations and specifications of CFDA, FDA, OECD and ICH.
  • Years of industry experience. Creative Biolabs provides a full range of standardized experimental technical services.
  • Project leader system. One-to-one technical connection ensure that the results are true and timely feedback.
  • High cost performance. Help customers to speed up the experiment process, reduce the total cost and shorten the time consumption.

If you have any questions, please contact our staff, we will answer and serve you immediately.

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*For Research Use Only. Not for use in diagnostic procedures.

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